Agent-based STI + HIV modeling · Built on Starsim
STIsim
STIsim is an agent-based modeling framework for simulating co-circulating sexually transmitted infections. Built on the Starsim architecture, it supports structured sexual networks, multiple co-transmitting infections (HIV, syphilis, chlamydia, gonorrhea, trichomoniasis, bacterial vaginosis, and others), risk-stratified populations, and a flexible intervention library spanning screening, testing, treatment, and prevention. It is implemented in pure Python, extensively tested and documented, and runs in seconds to minutes on a laptop.
pip install stisim
Just want HIVsim? It's included in the STIsim package, so there's nothing extra to install. Use it with import hivsim.
Mac
- Open Terminal (press ⌘-Space, type Terminal, press Enter).
- Paste this and press Enter:
curl -LsSf https://stisim.org/install.sh | sh
On Windows, double-click the downloaded file. If Windows warns about it, click More info → Run anyway.
git clone https://github.com/starsimhub/stisim.git
cd stisim
pip install -e .
Use pip install -e .[dev] to include test and docs dependencies.
Research
What has been done with the model, and what is under way.
Multiplex panel for vaginal discharge syndrome
Evaluation of a multiplex panel that gives an etiological diagnosis of vaginal discharge syndrome, detecting NG, CT and TV from symptomatic presentation, intended to replace syndromic management as the standard of care.
Two new syphilis diagnostics
Evaluation of two new syphilis diagnostics: one detecting syphilis from genital ulcer disease, and a confirmatory test used after an initial positive treponemal result.
Partner notification scenarios
An interactive scenario explorer for STI partner-notification strategies.
Vaginal microbiome study
An interactive dashboard on vaginal microbiome dynamics, HIV prevention, and preterm birth outcomes.
Downstream value of point-of-care tests
Building on the multiplex and syphilis work: what would it take for these point-of-care diagnostics to deliver a measurable improvement in health outcomes?
Value of asymptomatic STI screening in pregnancy
A value-of-information analysis of screening for asymptomatic NG, CT and TV during antenatal care.